While working on two sites with huge lists of fields in views, I threw together the views_ui_tamer module to make life just a bit easier.
The module will probably not make it to drupal.org, but there is a patch here: http://drupal.org/node/981094
This should work for views 2 and 3.
views_ui_tamer adds two ease-of-use features to the views ui.
1. The jquery quicksearch plugin is used to filter checkbox options in the add_item_form. This lets you quickly find a field, argument, filter, etc to add.